He cites research indicating that, in many cases of so-called "endogenous" depression, the depressed person had suffered some kind of serious emotional distress in the year before the onset of their depression. In Lost Connections: Uncovering the Real Causes of Depression and the Unexpected Solutions, Hari interrogates this dubious taxonomy. By contrast, “reactive” depression was caused by external events such as bereavement, trauma or some other adversity. Received wisdom held that “endogenous” depression was caused by a chemical imbalance in the brain antidepressants were supposed to solve the problem by restoring the brain’s natural balance. Like many people suffering from depression, Johann Hari spent many years taking the antidepressant drug Seroxat, a Selective Serotonin Reuptake Inhibitor, or SSRI.
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